The CBD compound is known for being an organic and safe substance.
However, all good things must have some “negative” side to balance out everything; think of it like the YinYang symbol.
● “Inhibition of hepatic drug metabolism/decreased ” (the breakdown of the CBD by the liver decreased) ” activities of p-glycoprotein and other drug transporters
● Dry mouth
● Increased tremor in some Parkinson’s patients
● Low blood pressure
● Lightheadedness
● Drowsiness”per elixinol.com
From personal experience, I can say that dry mouth and the light headedness were accurate symptoms but a little water and food can help that out pretty well, (HEALTHY FOOD!!!).
Now to elaborate on the points listed above:
“1. “Inhibition of hepatic drug
metabolism/decreased” (Slowdown of the liver to breakdown) “the CBD can indeed interact with a series of pharmaceuticals, as it inhibits the activity of some liver enzymes called cytochrome P450.This family of enzymes metabolizes most of the pharmaceutical drugs used to treat humans.
If one takes high doses of CBD, the cannabinoid can temporarily neutralize the activity of P450 enzymes and thus alter the way drugs are metabolized inside the body.
This action of CBD can be regarded as a side effect, but it’s not always a negative trait, as the deactivation of P450 enzymes is one of the mechanisms through which CBD neutralizes THC as well.
2. Dry mouth
Another reported side effect of CBD administration is an unpleasant dry sensation in the mouth.This effect seems to be caused by the involvement of the endocannabinoid system in the inhibition of saliva secretion.
A study published by Argentinian researchers back in 2006 showed that cannabinoid receptors (type 1 and 2) are present in the submandibular glands which are responsible for producing saliva.
The activation of these receptors alters the salivary production, leading to mouth dryness (also referred to as “cotton-mouth”).
Dry mouth will pretty much just make you thirsty.
3. Increased tremor in Parkinson’s disease at high dose CBD
Early research suggests that CBD taken in high doses may worsen tremor and muscle movement in Parkinson’s disease sufferers.
Yet, there are also studies that suggest that cannabidiol is safe and well-tolerated by patients affected by this condition.
If this occurs, reducing the dose should reduce this potential side effect.
Parkinson’s disease sufferers should consult their doctor before taking CBD and also begin any regimen by taking smaller doses.
4. Low blood pressure
Higher doses of CBD oil can cause a small drop in blood pressure, usually within a few minutes of the CBD entering your system.
This drop in blood pressure is often associated with a feeling of lightheadedness.
If you are taking medication for blood pressure, you should consult your doctor before taking CBD.
5. Lightheadedness
This can be caused by the drop in blood pressure that can affect those using higher doses.
This side effect of CBD is temporary and can often be resolved by drinking a cup of coffee or tea.
6. Drowsiness
In higher doses, CBD can cause drowsiness.
If you are affected this way, you should not operate machinery or drive a vehicle.
In most cases however, CBD is a wake-inducing agent.”
-Elixinol.com
Bottom line, proceed with caution and don’t overdo it!
Take care and respect the herb, do not abuse it because its job is to help you.
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